Your browser doesn't support javascript.
loading
Acute effect of prolactin on ornithine decarboxylase activity in the rat testis.
de Las Heras, M A; Calandra, R S.
Afiliação
  • de Las Heras MA; Laboratorio de Esteroides, Instituto de Biología y Medicina Experimental, Buenos Aires, Argentina.
Arch Androl ; 29(3): 271-9, 1992.
Article em En | MEDLINE | ID: mdl-1482216
A study was conducted to evaluate the effect of the acute treatment with prolactin (PRL) on ornithine decarboxylase (ODC) activity in the rat testis. Injection of a single SC dose of ovine PRL to puberal rats resulted in the activation of ODC from whole testis. This effect was maximal at 4 h after injection, and statistically significant at the dose of 500 micrograms. The effect of PRL was confined to the interstitial space; no change was observed in seminiferous tubules. PRL was unable to further increase testicular ODC activity when injected together with a stimulatory dose of human chorionic gonadotropin (hCG). The effect of PRL was mimicked by injection of a single dose of the dopamine antagonist sulpiride, which provoked a ninefold increase in serum PRL levels. In contrast, PRL did not stimulate testicular ODC activity in hypophysectomized rats, either under basal conditions or during treatment with PRL-hCG, indicating the requirement of a functional hypophysis for the expression of PRL action. These results suggest that the stimulation of testicular ODC activity by PRL is a marker of the trophic response of the testis to this hormone, different from the stimulation of steroidogenesis. This activity could be useful for the study of PRL action on the testis as well as of the interaction between PRL and LH at the testicular level.
Assuntos
Buscar no Google
Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Ornitina Descarboxilase / Prolactina / Testículo Limite: Animals Idioma: En Revista: Arch Androl Ano de publicação: 1992 Tipo de documento: Article País de afiliação: Argentina País de publicação: Reino Unido
Buscar no Google
Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Ornitina Descarboxilase / Prolactina / Testículo Limite: Animals Idioma: En Revista: Arch Androl Ano de publicação: 1992 Tipo de documento: Article País de afiliação: Argentina País de publicação: Reino Unido