Thyroidectomy blocks stress-induced prolactin rise in rats: role of the central serotonergic system.
Horm Metab Res
; 24(10): 462-5, 1992 Oct.
Article
em En
| MEDLINE
| ID: mdl-1464410
Thyroidectomized (TX) adult Wistar male rats and their sham-operated controls were submitted to immobilization stress during forty minutes. Thyroidectomy partially blocks stress-induced prolactin (PRL) secretion. Previous administration of MK 212, a serotonin agonist, reverts this picture. The effect of MK 212 is specifically due to its interaction with 5HT2 receptors, since the injection of LY 53857, a selective blocker of these receptors, 30 min before MK 212, prevents the effect of this serotonin agonist. LY 53857, injected alone, yields a partial blockade of PRL secretion during stress in sham-operated rats. TX rats receiving LY 53857 or saline have comparable low values of plasma PRL during stress. It is suggested that thyroidectomy disrupts the functional integrity of the central serotonergic pathways involved in the stress-induced PRL rise.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Prolactina
/
Pirazinas
/
Antagonistas da Serotonina
/
Estresse Psicológico
/
Tireoidectomia
/
Serotonina
/
Sistema Nervoso Central
/
Ergolinas
Limite:
Animals
Idioma:
En
Revista:
Horm Metab Res
Ano de publicação:
1992
Tipo de documento:
Article
País de afiliação:
Brasil
País de publicação:
Alemanha