Pro-apoptotic signals of the bcl-2 gene family in the rat uterus occurs in the night before the day of estrus and precedes ovulation.
Mol Cell Endocrinol
; 208(1-2): 31-9, 2003 Oct 31.
Article
em En
| MEDLINE
| ID: mdl-14580719
Although regression of the endometrium during the rat estrous cycle is a well-recognized event, little is known concerning the mechanisms involved in triggering apoptosis in the rat uterine epithelium. In an attempt to have a better understanding of the mechanisms underlying apoptosis during estrus, we evaluated the expression of several key apoptotic genes of the bcl-2 family during the transition from proestrus to estrus day in the rat. Our results show significant changes in the expression of bcl-2 family genes at midnight before estrus, characterized by a significant increase in the pro-apoptotic ratios: Bax/Bcl-2 and Bcl-xS/Bcl-xL at both mRNA and protein levels. Our results indicate the existence of a positive relation between apoptosis and pro-apoptotic ratios of bcl-2 gene family expression, during the transition from proestrus to estrus day. Importantly, pro-apoptotic signals were detected before ovulation occurred. The overall results suggest that the apoptotic process of the rat endometrium begins at midnight before the day of estrus, may be mediated by Bcl-2 family genes, and precedes ovulation.
Buscar no Google
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Útero
/
Apoptose
/
Proteínas Proto-Oncogênicas c-bcl-2
/
Ciclo Menstrual
Limite:
Animals
Idioma:
En
Revista:
Mol Cell Endocrinol
Ano de publicação:
2003
Tipo de documento:
Article
País de afiliação:
México
País de publicação:
Irlanda