Your browser doesn't support javascript.
loading
Plasmodium coatneyi-infected rhesus monkeys: a primate model for human cerebral malaria.
Aikawa, M; Brown, A E; Smith, C D; Tegoshi, T; Howard, R J; Hasler, T H; Ito, Y; Collins, W E; Webster, H K.
Afiliação
  • Aikawa M; Institute of Pathology, Case Western Reserve University, Cleveland, Ohio 44106.
Mem Inst Oswaldo Cruz ; 87 Suppl 3: 443-7, 1992.
Article em En | MEDLINE | ID: mdl-1343725
Although several animal models for human cerebral malaria have been proposed in the past, none have shown pathological findings that are similar to those seen in humans. In order to develop an animal model for human cerebral malaria, we studied the pathology of brains of Plasmodium coatneyi (primate malaria parasite)-infected rhesus monkeys. Our study demonstrated parasitized erythrocyte (PRBC) sequestration and cytoadherence of knobs on PRBC to endothelial cells in cerebral microvessels of these monkeys. This is similar to the findings seen in human cerebral malaria. Cerebral microvessels with sequestered PRBC were shown by immunohistochemistry to possess CD36, TSP and ICAM-1. These proteins were not evident in cerebral microvessels of uninfected control monkeys. Our study indicates, for the first time, that rhesus monkeys infected with P. coatneyi can be used as a primate model to study human cerebral malaria.
Assuntos
Buscar no Google
Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Plasmodium / Malária Cerebral / Modelos Animais de Doenças / Macaca mulatta Tipo de estudo: Prognostic_studies Limite: Animals / Humans Idioma: En Revista: Mem Inst Oswaldo Cruz Ano de publicação: 1992 Tipo de documento: Article País de publicação: Brasil
Buscar no Google
Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Plasmodium / Malária Cerebral / Modelos Animais de Doenças / Macaca mulatta Tipo de estudo: Prognostic_studies Limite: Animals / Humans Idioma: En Revista: Mem Inst Oswaldo Cruz Ano de publicação: 1992 Tipo de documento: Article País de publicação: Brasil