Plasmodium coatneyi-infected rhesus monkeys: a primate model for human cerebral malaria.
Mem Inst Oswaldo Cruz
; 87 Suppl 3: 443-7, 1992.
Article
em En
| MEDLINE
| ID: mdl-1343725
Although several animal models for human cerebral malaria have been proposed in the past, none have shown pathological findings that are similar to those seen in humans. In order to develop an animal model for human cerebral malaria, we studied the pathology of brains of Plasmodium coatneyi (primate malaria parasite)-infected rhesus monkeys. Our study demonstrated parasitized erythrocyte (PRBC) sequestration and cytoadherence of knobs on PRBC to endothelial cells in cerebral microvessels of these monkeys. This is similar to the findings seen in human cerebral malaria. Cerebral microvessels with sequestered PRBC were shown by immunohistochemistry to possess CD36, TSP and ICAM-1. These proteins were not evident in cerebral microvessels of uninfected control monkeys. Our study indicates, for the first time, that rhesus monkeys infected with P. coatneyi can be used as a primate model to study human cerebral malaria.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Plasmodium
/
Malária Cerebral
/
Modelos Animais de Doenças
/
Macaca mulatta
Tipo de estudo:
Prognostic_studies
Limite:
Animals
/
Humans
Idioma:
En
Revista:
Mem Inst Oswaldo Cruz
Ano de publicação:
1992
Tipo de documento:
Article
País de publicação:
Brasil