Dengue 2 virus enhancement in asthmatic and non asthmatic individual.
Mem Inst Oswaldo Cruz
; 87(4): 559-64, 1992.
Article
em En
| MEDLINE
| ID: mdl-1343671
During the 1981 dengue hemorrhagic fever/dengue shock syndrome (DHF/DSS) Cuban epidemic, bronchial asthma (BA) was frequently found as a personal or family antecedent in dengue hemorrhagic fever patients. Considering that antibody dependent enhancement (ADE) plays an important role in the etiopathogenic mechanism of DHF/DSS, we decide to study the Dengue 2 virus (D2V) capability of replication in peripheral blood leukocytes (PBL) from asthmatic patients and healthy persons. In 90% of asthmatic patients and 53.8% of control group it was obtained PBL with a significant D2V enhancing activity (X2 p < 0.01). Power enhancement was higher in asthmatic group. This is the first in vitro study relating BA and the dengue 2 virus immuno enhancement. The results obtained support the role of BA as a risk factor for DHF/DSS as already described on epidemiological data.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Asma
/
Replicação Viral
/
Dengue
/
Vírus da Dengue
Tipo de estudo:
Prevalence_studies
/
Risk_factors_studies
Limite:
Adolescent
/
Adult
/
Aged
/
Female
/
Humans
/
Male
/
Middle aged
País/Região como assunto:
Caribe
/
Cuba
Idioma:
En
Revista:
Mem Inst Oswaldo Cruz
Ano de publicação:
1992
Tipo de documento:
Article
País de afiliação:
Cuba
País de publicação:
Brasil