Hypoglycemic activity of some antidiabetic plants.
Arch Med Res
; 23(3): 105-9, 1992.
Article
em En
| MEDLINE
| ID: mdl-1308798
To assess the hypoglycemic activity mechanism of some plants used empirically by the Mexican population as antidiabetics, traditional preparations of Cucurbita ficifolia, Guaiacum coulteri, Lepechinia caulescens, and Psacalium peltatum, water, tolbutamide, and Regular Insulin were administered to three groups of rabbits each: 1. Healthy rabbits with temporary hyperglycemia induced by the subcutaneous administration of glucose. 2. Rabbits with moderate diabetes (fasting glycemia 150-300 mg/dl), induced with alloxan. 3. Rabbits with severe diabetes (fasting glycemia higher than 400 mg/dl), induced with alloxan. The plant preparations had a hypoglycemic effect similar to tolbutamide in healthy and mild diabetic rabbits and had no effect in severely diabetic rabbits. These results suggest that some pancreatic function or the presence of insulin is required for the hypoglycemic activity of these plants.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Plantas Medicinais
/
Diabetes Mellitus Experimental
/
Hipoglicemiantes
Limite:
Animals
País/Região como assunto:
Mexico
Idioma:
En
Revista:
Arch Med Res
Assunto da revista:
MEDICINA
Ano de publicação:
1992
Tipo de documento:
Article
País de publicação:
Estados Unidos