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IS6110 restriction fragment length polymorphism of Mycobacterium tuberculosis isolated from patients with pulmonary tuberculosis in Campinas, Brazil: evidence of intercontinental distribution of strains.
Calusni, Ana Lucia Roscani; Roscani, Gláucia Nogueira; Villares, Maria Cecília Barisson; Soini, Hanna; Graviss, Edward A; Ramos, Marcelo de Carvalho.
Afiliação
  • Calusni AL; Laboratório de Patogênese Bacteriana, Departamento de Clínica Médica, Faculdade de Ciências Médicas, Universidade Estadual de Campinas, Campinas, SP, 13083-970, Brasil.
Mem Inst Oswaldo Cruz ; 98(5): 655-8, 2003 Jul.
Article em En | MEDLINE | ID: mdl-12973533
Tuberculosis (TB) is a major concern in developing countries. In Brazil, few genotyping studies have been conducted to verify the number of IS6110 copies present in local prevalent strains of Mycobacterium tuberculosis, the distribution and clustering of strains. IS6110 DNA fingerprinting was performed on a sample of M. tuberculosis isolates from patients with AFB smear-positive pulmonary TB, at a hospital in Brazil. The IS6110 profiles were analyzed and compared to a M. tuberculosis database of the Houston Tuberculosis Initiative, Houston, US. Seventy-six fingerprints were obtained from 98 patients. All M. tuberculosis strains had an IS6110 copy number between 5-21 allowing for differentiation of the isolates. Human immunodeficiency virus infection was confirmed in nearly half the patients of whom data was available. Fifty-eight strains had unique patterns, while 17 strains were grouped in 7 clusters (2 to 6 strains). When compared to the HTI database, 6 strains matched isolates from El Paso, Ciudad de Juarez, Houston, and New York. Recently acquired infections were documented in 19% of cases. The community transmission of infection is intense, since some clustered strains were recovered during the four-year study period. The intercontinental dissemination of M. tuberculosis strains is suspected by demonstration of identical fingerprints in a distant country.
Assuntos
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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Tuberculose Pulmonar / Mycobacterium tuberculosis Limite: Humans País/Região como assunto: America do sul / Brasil Idioma: En Revista: Mem Inst Oswaldo Cruz Ano de publicação: 2003 Tipo de documento: Article País de afiliação: Brasil País de publicação: Brasil
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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Tuberculose Pulmonar / Mycobacterium tuberculosis Limite: Humans País/Região como assunto: America do sul / Brasil Idioma: En Revista: Mem Inst Oswaldo Cruz Ano de publicação: 2003 Tipo de documento: Article País de afiliação: Brasil País de publicação: Brasil