seco-iridoids from Calycophyllum spruceanum (Rubiaceae).
Phytochemistry
; 64(2): 549-53, 2003 Sep.
Article
em En
| MEDLINE
| ID: mdl-12943773
Three seco-iridoids 7-methoxydiderroside, 6'-O-acetyldiderroside and 8-O-tigloyldiderroside, were isolated from the wood bark of Calycophyllum spruceanum together with the known iridoids loganetin, loganin and the seco-iridoids secoxyloganin, kingiside and diderroside. Their structures were elucidated by means of NMR and MS spectral data analysis. Using NOE correlations and coupling constants, the relative stereochemistry of the new derivatives was established. 7-Methoxydiderroside, 6'-O-acetyldiderroside and the known secoxyloganin and diderroside showed in vitro activity against trypomastigote forms of Trypanosoma cruzi, with IC(50) values of 59.0, 90.2, 74,2 and 84.9 microg/mL, respectively and were compared to the standard gentian violet (IC(50) 7.5 microg/ml).
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Rubiaceae
/
Iridoides
Limite:
Animals
Idioma:
En
Revista:
Phytochemistry
Ano de publicação:
2003
Tipo de documento:
Article
País de afiliação:
Brasil
País de publicação:
Reino Unido