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Coinfection with Mycoplasma pneumoniae and Chlamydia pneumoniae in ruptured plaques associated with acute myocardial infarction.
Higuchi, Maria de Lourdes; Reis, Marcia Martins; Sambiase, Nádia Vieira; Palomino, Suely Aparecida Pinheiro; Castelli, Jussara Bianchi; Gutierrez, Paulo Sampaio; Aiello, Vera Demarchi; Ramires, José Antonio Franchini.
Afiliação
  • Higuchi Mde L; Instituto do Coração, Hospital das Clínicas, FMUSP, São Paulo, SP, Brasil. amplourdes@incor.usp.br
Arq Bras Cardiol ; 81(1): 12-22, 1-11, 2003 Jul.
Article em En, Pt | MEDLINE | ID: mdl-12908069
OBJECTIVE: To study atheromas, Mycoplasma pneumoniae (M. pneumoniae), and Chlamydia pneumoniae (C. pneumoniae). METHODS: C. pneumoniae was studied with immunohistochemistry and M. pneumoniae with in situ hybridization (ISH), in segments of coronary arteries (SCA) as follows: group A - thrombosed ruptured plaques (TRP) of 23 patients who died due to acute myocardial infarction (AMI); group B - 23 nonruptured plaques (NRP) of group A patients; group C - NRP of 11 coronary patients who did not die due to AMI; and group D - 11 SCA from patients with dilated cardiomyopathy or Chagas' disease without atherosclerosis. RESULTS: The mean number of C. pneumoniae+ cells/400x in groups A, B, C, and D was, respectively, 3.3 +/- 3.6; 1.0 +/- 1.3; 1.2 +/- 2.4; and 0.4 +/- 0.3; and the percentage of M. pneumoniae area was, respectively, 3.9 +/- 3.5; 1.5 +/- 1.6; 0.9 +/- 0.9; and 0.4 +/- 0.2. More M. pneumoniae and C. pneumoniae were found in of group A than in group B (P<0.01). Good correlation was seen between the area of the vessel and the M. pneumoniae area in the plaque (r = 0.46; P=0.001) and between C. pneumoniae+ cells and CD4+ T lymphocytes (r = 0.42; P<0.01). The number of C. pneumoniae+ cells correlated with CD20+ B cells (r=0.48; P<0.01). CONCLUSION: M. pneumoniae and C. pneumoniae are more frequently found in TRP correlate with the intensity of the inflammation and diameter of the vessel (positive remodeling).
Assuntos
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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Pneumonia por Mycoplasma / Doença da Artéria Coronariana / Infecções por Chlamydia / Infarto do Miocárdio Tipo de estudo: Risk_factors_studies Limite: Aged / Female / Humans / Male Idioma: En / Pt Revista: Arq Bras Cardiol Ano de publicação: 2003 Tipo de documento: Article País de afiliação: Brasil País de publicação: Brasil
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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Pneumonia por Mycoplasma / Doença da Artéria Coronariana / Infecções por Chlamydia / Infarto do Miocárdio Tipo de estudo: Risk_factors_studies Limite: Aged / Female / Humans / Male Idioma: En / Pt Revista: Arq Bras Cardiol Ano de publicação: 2003 Tipo de documento: Article País de afiliação: Brasil País de publicação: Brasil