DNA ploidy in cervical lesions assessed by computed image analysis: relation to histopathology.
Pathologica
; 95(2): 88-91, 2003 Apr.
Article
em En
| MEDLINE
| ID: mdl-12768877
OBJECTIVE: To assess the different patterns of DNA nuclear content in cervical intraepithelial neoplasia. STUDY DESIGN: DNA nuclear content patterns (DNA ploidy) were assessed in 82 paraffin embedded samples diagnosed as chronic cervicitis CIN 1, CIN 2 and CIN 3 by image analysis using the CAS200 BD System. These results were compared to the consensus diagnosis of two pathologists. The chi-square test was used to evaluate the results of classificatory variables (CIN 1, CIN 2 and CIN 3). RESULTS: Aneuploidy was found in 86% of CIN 3; 59% CIN 2; 26%% CIN 1. All samples classified as chronic cervicitis were diploid. CONCLUSIONS: The DNA nuclear content was found to parallel the three grades of the histological WHO classification. Aneuploidy was strongly associated with the high-grade lesions; the detection of a subset aneuploidy of low grade lesions would suggest a indicate closer follow-up of these cases.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Ploidias
/
Processamento de Imagem Assistida por Computador
/
DNA
/
Cervicite Uterina
/
Displasia do Colo do Útero
/
Neoplasias do Colo do Útero
Limite:
Female
/
Humans
Idioma:
En
Revista:
Pathologica
Ano de publicação:
2003
Tipo de documento:
Article
País de afiliação:
Brasil
País de publicação:
Itália