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Tolerance of a sterile isotonic electrolyte solution containing select recombinant growth factors in neonates recovering from necrotizing enterocolitis.
Lima-Rogel, Victoria; Calhoun, Darlene A; Maheshwari, Akhil; Torres-Montes, Abraham; Roque-Sanchez, Raul; Garcia, Maria G; Christensen, Robert D.
Afiliação
  • Lima-Rogel V; Division of Neonatology, Hospital General Dr. Ignacio Morones Prieto, San Luis Potosi City, San Luis Potosi, Mexico.
J Perinatol ; 23(3): 200-4, 2003.
Article em En | MEDLINE | ID: mdl-12732856
OBJECTIVE: To assess the tolerance of a sterile isotonic electrolyte solution containing select recombinant growth factors enterally administered in neonates who were NPO because of necrotizing enterocolitis (NEC). STUDY DESIGN: A phase I trial was accomplished among 30 neonates. Patients received 5, 10, or 20 mL enterally of the study solution/kg/day divided into every 3-hour dosing, for 3 days prior to when feedings of milk were to resume. The occurrence of emesis, gastric residuals, diarrhea, bloody stools, abdominal distention, skin rashes and death were sought. RESULTS: Gestational ages ranged from 25.2 to 41.1 weeks. A total of 16 neonates had Stage IA NEC, six Stage IB, and eight Stage IIA. The solution was well tolerated in all 30; none developed diarrhea, guaiac positive or bloody stools, or abdominal distention. Administration of the solution was not prematurely discontinued in any infant. Two neonates died secondary to late-onset sepsis remote from the study period. CONCLUSIONS: Enteral administration of a sterile isotonic electrolyte solution containing select recombinant growth factors was well tolerated by neonates with NEC.
Assuntos
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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Cloreto de Sódio / Fator Estimulador de Colônias de Granulócitos / Eritropoetina / Enterocolite Necrosante / Intestinos Limite: Humans / Newborn Idioma: En Revista: J Perinatol Assunto da revista: PERINATOLOGIA Ano de publicação: 2003 Tipo de documento: Article País de afiliação: México País de publicação: Estados Unidos
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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Cloreto de Sódio / Fator Estimulador de Colônias de Granulócitos / Eritropoetina / Enterocolite Necrosante / Intestinos Limite: Humans / Newborn Idioma: En Revista: J Perinatol Assunto da revista: PERINATOLOGIA Ano de publicação: 2003 Tipo de documento: Article País de afiliação: México País de publicação: Estados Unidos