Evidence suggesting that chlorophyllin (CHLN) may act as an inhibitor or a promoter of genetic damage induced by chromium(VI) oxide (CrO3) in somatic cells of Drosophila.
Mutat Res
; 536(1-2): 139-44, 2003 Apr 20.
Article
em En
| MEDLINE
| ID: mdl-12694754
In Drosophila, 48h-old larvae were pretreated for 24h with chlorophyllin (CHLN) or sucrose and then treated with chromium(VI) oxide (CrO(3)) immediately following completion of the pretreatment period (0-day delay) or delayed 1, 2 or 3 days. The effects were scored in the wing spot test. After delays of 0 and 1 day, clear evidence of a protective effect of CHLN was found. Contrarily, after delays of 2 and 3 days, the results showed a reversal, i.e. CHLN-related events appeared more frequently than those in the sucrose control suggesting a promoting effect. It would appear prudent that CHLN be tested in a variety of situations in any given organism before decisions are reached regarding its inhibitor/promoter effects.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Clorofilídeos
/
Antimutagênicos
/
Compostos de Cromo
/
Drosophila
Tipo de estudo:
Prognostic_studies
Limite:
Animals
Idioma:
En
Revista:
Mutat Res
Ano de publicação:
2003
Tipo de documento:
Article
País de afiliação:
México
País de publicação:
Holanda