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In vitro evaluation of the cytotoxicity of two root canal sealers on macrophage activity.
de Oliveira Mendes, Sônia Teresa; Ribeiro Sobrinho, Antônio Paulino; de Carvalho, André Teixeira; de Souza Côrtes, Maria Ilma; Vieira, Leda Quercia.
Afiliação
  • de Oliveira Mendes ST; Departamento de Odontologia Restauradora, Faculdade de Odontologia, Universidade Federal de Minas Gerais, MG, Brazil.
J Endod ; 29(2): 95-9, 2003 Feb.
Article em En | MEDLINE | ID: mdl-12597705
Although some studies have been concerned with the cytotoxicity of endodontic sealers and their components, few have approached the effects of endodontic sealers on macrophage viability and activity. In this study the effect of two zinc oxide-eugenol-based sealers, freshly prepared or after setting for 24 h, was determined on macrophage activity in vitro. Sealers were placed inside a glass capillary tube and added to mouse-elicited macrophage cultures. Sealers did not affect macrophage viability; however, adherence to glass and phagocytosis were impaired. Moreover, nitric oxide production in response to activation with interferon-gamma was diminished, but interleukin-12 production in response to Listeria monocytogenes was not altered. Interestingly, freshly mixed and solid test samples had similar inhibitory activities. In conclusion, the tested sealers did not affect a pro-inflammatory response (interleukin-12 production) but had an inhibitory effect on the effector responses measured (phagocytosis and nitric oxide production).
Assuntos
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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Materiais Restauradores do Canal Radicular / Macrófagos Peritoneais Limite: Animals Idioma: En Revista: J Endod Ano de publicação: 2003 Tipo de documento: Article País de afiliação: Brasil País de publicação: Estados Unidos
Buscar no Google
Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Materiais Restauradores do Canal Radicular / Macrófagos Peritoneais Limite: Animals Idioma: En Revista: J Endod Ano de publicação: 2003 Tipo de documento: Article País de afiliação: Brasil País de publicação: Estados Unidos