Fibrinogen: intra-individual variability in patients with arterial disease and in patients with cardiac valve replacements.
Isr Med Assoc J
; 4(11): 992-5, 2002 Nov.
Article
em En
| MEDLINE
| ID: mdl-12489488
BACKGROUND: Elevated fibrinogen, considered an independent risk factor for coronary disease, stratifies an individual as high risk for coronary disease. A risk marker requires little intra-individual variability during a long period. OBJECTIVES: To establish intra-individual variability of fibrinogen levels in patients with coronary disease. METHODS: We investigated fibrinogen levels prospectively in four blood samples drawn from 267 patients with a history of arterial disease (arterial group) and from 264 patients with cardiac valve replacements (valvular group). The samples were taken during the course of 78.7 and 78.8 days from the arterial and valvular groups respectively. RESULTS: Marked intra-individual dispersion with a reliability coefficient of 0.541 was found in the arterial group and 0.547 in the valvular group. The Bland-Altman test showed low probability to obtain similar results in different samples from the same individual. These results show large intra-individual variability, with similarities in the arterial as well as in the valvular group. CONCLUSIONS: It is not possible to stratify a patient by a specific fibrinogen dosage.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Fibrinogênio
/
Doença das Coronárias
Tipo de estudo:
Observational_studies
/
Risk_factors_studies
Limite:
Humans
Idioma:
En
Revista:
Isr Med Assoc J
Assunto da revista:
MEDICINA
Ano de publicação:
2002
Tipo de documento:
Article
País de afiliação:
Argentina
País de publicação:
Israel