Juice and phenolic fractions of the berry Aristotelia chilensis inhibit LDL oxidation in vitro and protect human endothelial cells against oxidative stress.
J Agric Food Chem
; 50(26): 7542-7, 2002 Dec 18.
Article
em En
| MEDLINE
| ID: mdl-12475268
Oxidative modification of low-density lipoprotein (LDL) particles is a key event in the development of atherosclerosis. Oxidized LDL induces oxidative stress and modifies gene expression in endothelial cells. Berries constitute a rich dietary source of phenolic antioxidants. We found that the endemic Chilean berry Aristotelia chilensis (ach) has higher phenol content and scores better for total radical-trapping potential and total antioxidant reactivity in in vitro antioxidant capacity tests, when compared to different commercial berries. The juice of ach is also effective in inhibiting copper-induced LDL oxidation. In human endothelial cell cultures, the addition of ach juice significantly protects from hydrogen peroxide-induced intracellular oxidative stress and is dose-dependent. The aqueous, anthocyanin-rich fraction of ach juice accounts for most of ach's antioxidant properties. These results show that ach is a rich source of phenolics with high antioxidant capacity and suggest that it may have antiatherogenic properties.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Fenóis
/
Endotélio Vascular
/
Magnoliopsida
/
Frutas
/
Lipoproteínas LDL
/
Antioxidantes
Limite:
Humans
País/Região como assunto:
America do sul
/
Chile
Idioma:
En
Revista:
J Agric Food Chem
Ano de publicação:
2002
Tipo de documento:
Article
País de afiliação:
Chile
País de publicação:
Estados Unidos