Defect of NK regulation in HIV-infected patients.
Arch AIDS Res
; 6(1-2): 15-26, 1992.
Article
em En
| MEDLINE
| ID: mdl-12344006
PIP: In Buenos Aires, Argentina, health workers obtained peripheral blood samples from 22 HIV-infected people with either no symptoms or persistent lymphadenopathy to examine natural killer cytotoxicity (NKC) of asymptomatic HIV-infected (HIV+AS) cases and the effect of factors that regulate normal NKC. Researchers compared these results with those of 10 healthy heterosexual controls. Even though NK cells of the HIV+AS cases were present in the same numbers and functioned as well as those in the controls, an inducer of interferon (Concanavalin A or ConA) could not force the cell system in vitro which demonstrated NK defectiveness. NK response to ConA of HIV+AS cases was lower than that of the healthy controls (p.05). On the other hand, the NK response to a prostaglandin antagonist (Indomethacin or IM) matched that of the healthy controls. Cell supernatants from normal peripheral blood mononuclear cells increased normal NK cell function (p.001), but those from HIV+AS cases did not do so. Thus it appeared that the HIV+AS cases were unable to produce sufficient NK enhancer factors. Cell supernatants from HIV+AS reduced normal NKC below baseline (p.05) indicating the presence of NK suppressor factors. The researchers believed products of the arachidonic acid metabolism by the cyclooexgenase pathway, maybe PGE2, may have contributed to NK suppression since IM negated suppressor activity of cell supernatants from HIV+AS subjects on normal NK function. They concluded that reduced production of enhancing factors, additional release of inhibitory factors, and deficiency at the NK effector system are likely to be the underlying causes for NK deficient function in AIDS. They noted that these effects function synergistically.^ieng
Palavras-chave
Americas; Argentina; Behavior; Biology; Case Control Studies; Clinical Research; Cytologic Effects; Developing Countries; Diseases; Drug Usage; Drugs; Endocrine System; Examinations And Diagnoses; Hematologic Tests; Hiv Infections; Homosexuals; Immunity; Immunity, Cellular; In Vitro; Iv Drug Users; Laboratory Examinations And Diagnoses; Laboratory Procedures; Latin America; Methodological Studies; Physiology; Prostaglandin Antagonists; Prostaglandins; Research Methodology; Sex Behavior; South America; Studies; Treatment; Viral Diseases
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Antagonistas de Prostaglandina
/
Pesquisa
/
Preparações Farmacêuticas
/
Homossexualidade
/
Estudos de Casos e Controles
/
Infecções por HIV
/
Abuso de Substâncias por Via Intravenosa
/
Células
/
Testes Hematológicos
/
Imunidade Celular
Tipo de estudo:
Diagnostic_studies
/
Observational_studies
País/Região como assunto:
America do sul
/
Argentina
Idioma:
En
Revista:
Arch AIDS Res
Ano de publicação:
1992
Tipo de documento:
Article
País de publicação:
Estados Unidos