Novel cytotoxic oxygenated C29 sterols from the Colombian marine sponge Polymastia tenax.
J Nat Prod
; 65(8): 1161-4, 2002 Aug.
Article
em En
| MEDLINE
| ID: mdl-12193022
Three new sterols, 5alpha,6alpha-epoxy-24R-ethylcholest-8(14)-en-3beta,7alpha-diol (1), 5alpha,6alpha-epoxy-24R-ethylcholest-8-en-3beta,7alpha-diol (2), and 3beta-hydroxy-24R-ethylcholesta-5,8-dien-7-one (3), have been isolated from the marine sponge Polymastia tenax, collected in the Colombian Caribbean, and their structures established on the basis of extensive NMR and MS studies. Compounds 1 and 2 showed antiproliferative activity toward A-549, HT-29, H-116, MS-1, and PC-3 tumor cells in the range 0.5-10 microg/mL.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Poríferos
/
Esteróis
Limite:
Animals
/
Humans
/
Male
País/Região como assunto:
America do sul
/
Colombia
Idioma:
En
Revista:
J Nat Prod
Ano de publicação:
2002
Tipo de documento:
Article
País de afiliação:
Espanha
País de publicação:
Estados Unidos