Involvement of NMDA receptors in the pressor response to microinjection of 5-HT3 agonist into the NTS of awake rats.
Auton Neurosci
; 98(1-2): 2-6, 2002 Jun 28.
Article
em En
| MEDLINE
| ID: mdl-12144032
Previous studies have shown that the activation of 5-HT3 receptors in the nucleus tractus solitarii (NTS) increases the baseline mean arterial pressure (MAP). In the present study, we evaluated the possible involvement of NMDA receptors in this pressor response. Four days before the experiments, under tribromoethanol anesthesia, rats received two guide cannulas in the direction of the NTS, and 1 day before the experiments, under tribromoethanol anesthesia, the femoral artery was cannulated for pulsatile arterial pressure (PAP), MAP, and heart rate (HR) measurements. On the day of the experiments, 2-methyl-serotonin, a 5-HT3 agonist, was microinjected into the NTS after microinjection of saline or AP-5, a selective NMDA receptor antagonist. Microinjection of 2-methyl-serotonin (5 nmol/50 nl) into the NTS after the vehicle (saline) produced a significant increase in MAP (+ 20 +/- 5 mm Hg, n = 8) while microinjection of 2-methyl-serotonin after microinjection of AP-5 (10 nmol/50 nl) produced no change in baseline MAP (-1 +/- 3 mm Hg, n = 11). Microinjection of AP-5 into the NTS produced no significant changes in the baseline MAP and HR. The data show that the increase in MAP in response to microinjection of a 5-HT3 agonist into the NTS is dependent on NMDA receptors.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Pressão Sanguínea
/
Serotonina
/
Agonistas do Receptor de Serotonina
/
Receptores de N-Metil-D-Aspartato
/
Núcleo Solitário
Limite:
Animals
Idioma:
En
Revista:
Auton Neurosci
Assunto da revista:
NEUROLOGIA
Ano de publicação:
2002
Tipo de documento:
Article
País de afiliação:
Brasil
País de publicação:
Holanda