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Predictors of developmental disabilities after open heart surgery in young children with congenital heart defects.
Limperopoulos, Catherine; Majnemer, Annette; Shevell, Michael I; Rohlicek, Charles; Rosenblatt, Bernard; Tchervenkov, Christo; Darwish, H Z.
Afiliação
  • Limperopoulos C; School of Physical and Occupational Therapy, Departments of Neurology and Neurosurgery, McGill University-Montreal Children's Hospital, Québec, Canada.
J Pediatr ; 141(1): 51-8, 2002 Jul.
Article em En | MEDLINE | ID: mdl-12091851
OBJECTIVES: To determine the prevalence of persistent developmental impairments in children with congenital heart defects and to identify factors that enhance risk for an adverse outcome. STUDY DESIGN: Eligible infants (n = 131) <2 years of age requiring open heart surgery were recruited prospectively. Subjects were assessed during surgery and again 12 to 18 months later with standardized developmental assessments and formal neurologic examinations. RESULTS: Mean age at follow-up testing was 19.1 +/- 6.6 months. Assessments indicated that 41% had abnormal neurologic examinations. Gross and/or fine motor delays were documented in 42%, and 23% demonstrated global developmental delay. Univariate and multiple regression models identified the following factors increasing the risk for persistent developmental deficits: preoperative and acute postoperative neurodevelopmental status and microcephaly, type of heart lesion, length of deep hypothermic circulatory arrest, age at surgery, and days in the intensive care unit (P <.05). CONCLUSIONS: Children with congenital heart defects commonly have ongoing neurologic, motor, and developmental deficits well after surgical correction. The cause is multifactorial and includes brain injury before, during, and after heart surgery.
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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Complicações Pós-Operatórias / Ponte Cardiopulmonar / Deficiências do Desenvolvimento / Transtornos das Habilidades Motoras / Cardiopatias Congênitas Tipo de estudo: Etiology_studies / Observational_studies / Prevalence_studies / Prognostic_studies / Risk_factors_studies Limite: Humans / Infant / Newborn País/Região como assunto: America do norte Idioma: En Revista: J Pediatr Ano de publicação: 2002 Tipo de documento: Article País de afiliação: Canadá País de publicação: Estados Unidos
Buscar no Google
Adicionar na Minha BVS
Imprimir
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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Complicações Pós-Operatórias / Ponte Cardiopulmonar / Deficiências do Desenvolvimento / Transtornos das Habilidades Motoras / Cardiopatias Congênitas Tipo de estudo: Etiology_studies / Observational_studies / Prevalence_studies / Prognostic_studies / Risk_factors_studies Limite: Humans / Infant / Newborn País/Região como assunto: America do norte Idioma: En Revista: J Pediatr Ano de publicação: 2002 Tipo de documento: Article País de afiliação: Canadá País de publicação: Estados Unidos