[Stereologic study of the cerebellar Purkinje cells submitted to alcoholic intoxication in Wistar rats]. / Estudo estereológico das células de Purkinje cerebelares submetidas à intoxicação alcoólica em ratos Wistar.
Arq Neuropsiquiatr
; 60(2-A): 258-63, 2002 Jun.
Article
em Pt
| MEDLINE
| ID: mdl-12068356
BACKGROUND: to analyze the effect of the alcohol on the cells of Purkinje. METHOD: Wistar rats received alcoholic solutions orally in different concentrations 4%, 12% and 24%. The animals were sacrificed with 4, 8 and 12 weeks and the cerebella were randomly cut and embedded in paraffin. Sections of 6 micrometer (H&E) were stereologically analyzed. RESULTS: The differences among the density for area and density of surface of the cells of Purkinje of all of the experimental groups (E) and the respective controls (C) were significant. With 12 weeks the cell of Purkinje volume density decreased among the groups C and E in the concentrations of 4% and 12%, but not for the concentration of 24%, probably due to smaller liquid ingestion by the animals. CONCLUSION: The alcohol has toxic effect on the Purkinje cellular body in the three studied concentrations from 4 weeks.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Células de Purkinje
/
Depressores do Sistema Nervoso Central
/
Etanol
/
Intoxicação Alcoólica
Limite:
Animals
Idioma:
Pt
Revista:
Arq Neuropsiquiatr
Ano de publicação:
2002
Tipo de documento:
Article
País de afiliação:
Brasil
País de publicação:
Alemanha