Novel phthalimide derivatives, designed as leukotriene D(4) receptor antagonists.
Bioorg Med Chem Lett
; 12(11): 1533-5, 2002 Jun 03.
Article
em En
| MEDLINE
| ID: mdl-12031336
A series of phthalimide acid derivatives was synthesized and evaluated as leukotriene D(4) receptor antagonists. The tetrazolephthalimide LASSBio 552 (7) was shown to be able to inhibit the contractile activity induced by 100 nM of LTD(4) in guinea-pig tracheal strips with an IC(50) = 31.2 microM. In addition, LASSBio 552 (7) has been showed to present a better efficacy than zafirlukast (1) used as standard.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Ftalimidas
/
Antiasmáticos
/
Antagonistas de Leucotrienos
/
Proteínas de Membrana
Limite:
Animals
Idioma:
En
Revista:
Bioorg Med Chem Lett
Assunto da revista:
BIOQUIMICA
/
QUIMICA
Ano de publicação:
2002
Tipo de documento:
Article
País de afiliação:
Brasil
País de publicação:
Reino Unido