Central 5-HT3 receptor stimulation by m-CPBG increases blood glucose in rats.
Horm Metab Res
; 34(2): 55-61, 2002 Feb.
Article
em En
| MEDLINE
| ID: mdl-11972287
The aim of the present study was to investigate the role of central 5-HT3 receptors on the control of blood glucose in stressed and non-stressed rats in both fasted and fed states. Adult Wistar male rats had each their third ventricle cannulated 7 days before the experiments. Injections of m-CPBG, a selective 5-HT3 receptor agonist, induced a significant increase in blood glucose in non-stressed rats in both fasted and in fed states. The same procedure was unable to modify stress-induced hyperglycemia. The hyperglycemic effect of m-CPBG central administration was blocked by pretreatment with ondansetron, a specific 5-HT3 receptor antagonist, indicating that the effects here obtained with m-CPBG were a result of its interaction with 5-HT3 receptors. Third ventricle injections of ondansetron alone were not able to modify blood glucose in non-stressed animals and did not change the hyperglycemic responses observed after immobilization stress. We conclude that pharmacological activation of the central 5-HT3 receptor induces a hyperglycemic effect in non-stressed animals.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Biguanidas
/
Glicemia
/
Receptores de Serotonina
/
Agonistas do Receptor de Serotonina
Limite:
Animals
Idioma:
En
Revista:
Horm Metab Res
Ano de publicação:
2002
Tipo de documento:
Article
País de afiliação:
Brasil
País de publicação:
Alemanha