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Gastrointestinal pneumatosis after docetaxel chemotherapy.
Candelaria, Myrna; Bourlon-Cuellar, Rene; Zubieta, José Luis García-Lascurain; Noel-Ettiene, Luoise Marie; Sánchez-Sánchez, J Manuel.
Afiliação
  • Candelaria M; Hospital Angeles del Pedregal, Mexico. myrna@aztlan.innsz.mx
J Clin Gastroenterol ; 34(4): 444-5, 2002 Apr.
Article em En | MEDLINE | ID: mdl-11907358
Breast cancer is one of the most frequent neoplasms in women. New drugs, including taxanes, have improved survival in patients with metastatic disease. Quality of life and efficacy are important goals during treatment of these women. Herein, we report a 51 year-old woman with metastatic breast cancer who developed gastrointestinal pneumatosis (GIP) after the first cycle of treatment, which consisted of docetaxel and pamidronate. The symptoms disappeared after 7 days with supportive management, nasogastric intubation, parenteral fluids, and wide-spectrum antibiotics. Thereafter, weekly fractionated chemotherapy with an initial 50% dose reduction was administered. Because of adequate tolerance, the dose was increased by 25% after the second cycle, and full-dose docetaxel was administered after the third cycle. After 6 months of follow-up, the patient remained under treatment, with an Eastern Cooperative Oncology Group performance status of 1. Gastrointestinal pneumatosis has been reported in association with chemotherapy. In most patients, it is reported to be associated with neutropenia, which was not present in this patient.
Assuntos
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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Pneumatose Cistoide Intestinal / Paclitaxel / Taxoides / Antineoplásicos Fitogênicos Aspecto: Patient_preference Limite: Female / Humans / Middle aged Idioma: En Revista: J Clin Gastroenterol Ano de publicação: 2002 Tipo de documento: Article País de afiliação: México País de publicação: Estados Unidos
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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Pneumatose Cistoide Intestinal / Paclitaxel / Taxoides / Antineoplásicos Fitogênicos Aspecto: Patient_preference Limite: Female / Humans / Middle aged Idioma: En Revista: J Clin Gastroenterol Ano de publicação: 2002 Tipo de documento: Article País de afiliação: México País de publicação: Estados Unidos