Effects of 3-chloro-phenyl-1,4-dihydropyridine derivatives on Trypanosome cruzi epimastigotes.

Maya, J D; Morello, A; Repetto, Y; Tellez, R; Rodriguez, A; Zelada, U; Puebla, P; Caballero, E; Medarde, M; Núñez-Vergara, L J; Squella, J A; Bontá, M; Bollo, S; San Feliciano, A

Maya, J D; Morello, A; Repetto, Y; Tellez, R; Rodriguez, A; Zelada, U; Puebla, P; Caballero, E; Medarde, M; Núñez-Vergara, L J; Squella, J A; Bontá, M; Bollo, S; San Feliciano, A.

Afiliação

Maya JD; Program of Clinical and Molecular Pharmacology, Institute of Biomedical Sciences, Faculty of Medicine, University of Chile, PO Box 70086, Santiago, Chile.

Comp Biochem Physiol C Toxicol Pharmacol ; 125(1): 103-9, 2000 Jan.

Article em En | MEDLINE | ID: mdl-11790334

RESUMO

A series of 3-chloro-phenyl-1,4-dihydropyridine derivatives produced different degrees of inhibition of parasite growth and respiration on clone Brener, LQ and Tulahuen strains of Trypanosome cruzi epimastigotes. Respiratory chain inhibition appears to be a posible determinant of the trypanosomicidal activity of this compounds. No difference in the action of these derivatives was found among the different parasite strains. For comparative purposes, the inhibitory effects of felodipine and nicardipine are also reported. A good correlation between toxic effects and the easiness of oxidation of the dihydripyridine ring was found. The presence of a fused ring on the dihydropyridine moiety significantly diminished the inhibitory effects.

Assuntos

Di-Hidropiridinas/farmacologia; Tripanossomicidas/farmacologia; Trypanosoma cruzi/efeitos dos fármacos; Animais; Bloqueadores dos Canais de Cálcio/farmacologia; Movimento Celular/efeitos dos fármacos; Di-Hidropiridinas/química; Eletroquímica; Felodipino/farmacologia; Nicardipino/farmacologia; Oxirredução; Consumo de Oxigênio/efeitos dos fármacos; Tripanossomicidas/química; Trypanosoma cruzi/crescimento & desenvolvimento; Trypanosoma cruzi/metabolismo

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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Tripanossomicidas / Trypanosoma cruzi / Di-Hidropiridinas Limite: Animals Idioma: En Revista: Comp Biochem Physiol C Toxicol Pharmacol Assunto da revista: FARMACOLOGIA / TOXICOLOGIA Ano de publicação: 2000 Tipo de documento: Article País de afiliação: Chile País de publicação: Estados Unidos

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