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[Analysis of HLA-DR in Mexican patients with pemphigus]. / Análisis de HLA-DR en pacientes mexicanos con pénfigo.
Vega-Memije, M E; Sáez de Ocariz-Gutiérrez, M M; Cortés-Franco, R; Domínguez-Soto, L; Granados-Arriola, J.
Afiliação
  • Vega-Memije ME; Departamento de Dermatología del Hospital General Dr. Manuel Gea González, Tlalpan 4800, Col. Toriello Guerra, 14000, Tlalpan México, D.F.
Gac Med Mex ; 137(6): 535-40, 2001.
Article em Es | MEDLINE | ID: mdl-11766460
UNLABELLED: Pemphigus are a group of bullous skin disorders histologically characterized by intraepidermal acantholytic and circulating antibodies blisters due to directed against the cellular surface of keratinocytes. In Mexican patients with pemphigus, HLA antigens have not been studied as they have been for other populations; for this reason, a comparative, prospective, transversal and observational study has been done with 25 patients, 18 with pemphigus vulgaris and the other seven with pemphigus foliaceus. DNA was extracted by the salting-out method and HLA-DR was determined by amplification with PCR and allele-specific oligonucleotides (ASO). RESULTS: HLA-DR14 (DR6) is more common in patients with pemphigus vulgaris than in the healthy population, which corroborates with previous reports. On the other hand, as reported we also found that HLA-DR1 in Mexican population represents a higher risk for pemphigus foliaceus.
Assuntos
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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Antígenos HLA-DR / Pênfigo Tipo de estudo: Observational_studies / Prevalence_studies / Risk_factors_studies Limite: Adult / Female / Humans / Male / Middle aged País/Região como assunto: Mexico Idioma: Es Revista: Gac Med Mex Ano de publicação: 2001 Tipo de documento: Article País de publicação: México
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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Antígenos HLA-DR / Pênfigo Tipo de estudo: Observational_studies / Prevalence_studies / Risk_factors_studies Limite: Adult / Female / Humans / Male / Middle aged País/Região como assunto: Mexico Idioma: Es Revista: Gac Med Mex Ano de publicação: 2001 Tipo de documento: Article País de publicação: México