Experimental treatment of chronic Trypanosoma cruzi infection in mice with 2-n-propylquinoline.
Phytother Res
; 15(7): 630-2, 2001 Nov.
Article
em En
| MEDLINE
| ID: mdl-11746849
It was reported previously that 2-n-propylquinoline was active against the epimastigote form of Trypanosoma cruzi. The effects of oral treatments with benznidazole and 2-n-propylquinoline were evaluated in Balb/c mice infected with T. cruzi chronically. The reference drug and 2-n-propylquinoline were administered 60 days post-infection for 30 days at 25 mg/mL. At 35 days post-treatment, the serological tests (ELISA) of the 2-n- propylquinoline-treated mice were significantly different from the controls (p = 0.01) and the benznidazole-treated mice (p = 0.03), while this was not the case at 85 days post-treatment. These results are encouraging for continuing the investigation of other analogues of 2-n-propylquinoline in experimental chronic Chagas' disease.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Quinolinas
/
Tripanossomicidas
/
Trypanosoma cruzi
/
Doença de Chagas
/
Rutaceae
/
Fitoterapia
Limite:
Animals
Idioma:
En
Revista:
Phytother Res
Assunto da revista:
TERAPIAS COMPLEMENTARES
Ano de publicação:
2001
Tipo de documento:
Article
País de afiliação:
Paraguai
País de publicação:
Reino Unido