Successful use of a defined antigen/GM-CSF adjuvant vaccine to treat mucosal Leishmaniasis refractory to antimony: A case report.
Braz J Infect Dis
; 5(4): 223-32, 2001 Aug.
Article
em En
| MEDLINE
| ID: mdl-11712967
Immunotherapy has been proposed as a method to treat mucosal leishmaniasis for many years, but the approach has been hampered by poor definition and variability of antigens used, and results have been inconclusive. We report here a case of antimonial-refractory mucosal leishmaniasis in a 45 year old male who was treated with three single injections (one per month) with a cocktail of four Leishmania recombinant antigens selected after documented hypo-responsiveness of the patient to these antigens, plus 50 microg of GM-CSF as vaccine adjuvant. Three months after treatment, all lesions had resolved completely and the patient remains without relapse after two years. Side effects of the treatment included only moderate erythema and induration at the injection site after the second and third injections. We conclude that carefully selected microbial antigens and cytokine adjuvant can be successful as immunotherapy for patients with antimonial-refractory mucosal leishmaniasis.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Leishmaniose Mucocutânea
/
Fator Estimulador de Colônias de Granulócitos e Macrófagos
/
Imunoterapia
/
Úlcera da Perna
/
Leishmania
/
Antígenos de Protozoários
Limite:
Animals
/
Humans
/
Male
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Middle aged
Idioma:
En
Revista:
Braz J Infect Dis
Assunto da revista:
DOENCAS TRANSMISSIVEIS
Ano de publicação:
2001
Tipo de documento:
Article
País de afiliação:
Brasil
País de publicação:
Brasil