[Oral hairy leukoplakia: histopathologic features of subclinical stage]. / Leucoplasia pilosa oral: aspectos histopatológicos da fase subclínica.
Pesqui Odontol Bras
; 15(2): 104-11, 2001.
Article
em Pt
| MEDLINE
| ID: mdl-11705191
Oral hairy leukoplakia (OHL) is one of the most common oral manifestations of AIDS, with diagnostic and prognostic value. OHL is associated to the Epstein-Barr virus and presents clinical and histological defined characteristics. There have already been reports about a subclinical stage of OHL, although they lacked histopathologic characterization. The present study had the aim to describe the histopathological characteristics of subclinical hairy leukoplakia, as well as to carry out a comparative analysis between clinical and subclinical OHL. For that, 11 cases were analyzed--5 biopsies from patients who presented with the lesion and 6 samples from the borders of tongues obtained in necropsies. The histopathological findings in subclinical OHL were: absence of parakeratosis and papillomatosis, mild acanthosis, ballooning cells and nuclear alterations. In situ hybridization and immunostaining were positive for EBV in the nuclear alterations identified in the histopathological analysis. Based on the identification of EBV in the nuclear alterations, it was possible to conclude that subclinical OHL, similarly to the clinical lesion, presents histopathological features that are specific and sufficient to establish the definitive diagnosis, regardless of the identification of the virus.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Leucoplasia Pilosa
Tipo de estudo:
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Limite:
Adult
/
Female
/
Humans
/
Male
/
Middle aged
Idioma:
Pt
Revista:
Pesqui Odontol Bras
Assunto da revista:
ODONTOLOGIA
Ano de publicação:
2001
Tipo de documento:
Article
País de publicação:
Brasil