Red blood cells Li+-Na+ exchange kinetics. Normal adolescents with hypertensive ancestors.
Acta Physiol Pharmacol Bulg
; 25(3-4): 81-5, 2000.
Article
em En
| MEDLINE
| ID: mdl-11688551
Li/Na exchange kinetic parameters (Km, Vmax) were determined in red blood cells from normal adolescents with or without hypertensive antecessors, as well as plasmatic levels of high density lipoproteins. In red blood cells from adolescents with hypertensive antecessors, we observed significantly lower Km values compared to the other group. HDL-c (high density lipoprotein-cholesterol) plasmatic values did not differ significantly. Furthermore, in normal adolescents without hypertensive ancestors, the Vmax significantly correlated with the HDL-c plasmatic values. The results indicated that the Km parameter of this transport mechanism is affected by genetic factors and data are also presented to demonstrate that the Vmax parameter is affected by environmental (cellular) factors. It is suggested that Li/Na exchange Km values would be a risk index of essential hypertension development.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Sódio
/
Eritrócitos
/
Hipertensão
/
Lítio
Tipo de estudo:
Prognostic_studies
Limite:
Adolescent
/
Humans
Idioma:
En
Revista:
Acta Physiol Pharmacol Bulg
Ano de publicação:
2000
Tipo de documento:
Article
País de afiliação:
Argentina
País de publicação:
Bulgária