Minimal-lesion nephrotic syndrome with early resistance to steroid therapy.
J Pediatr
; 87(3): 377-80, 1975 Sep.
Article
em En
| MEDLINE
| ID: mdl-1165516
The initial and long-term clinical course of six children with steroid-resistant, minimal-lesion nephrotic syndrome was evaluated. All children experienced remission after two to five weeks of combined cyclophosphamide-prednisone therapy. Following cyclophosphamide treatment, three patients have relapsed and have become steroid sensitive. The clinical outcome was quite favorable. These data suggest: (1) cyclophosphamide may induce a prompt remission in patients with minimal glomerular lesions who have early resistance to corticosteroids; (2) relapses which occur after cyclophosphamide should be treated with prednisone alone, even though the patient was previously steroid resistant; (3) the ultimate outcome is related more to the nature of the histopathologic lesion than to a lack of steroid responsiveness.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Prednisona
/
Ciclofosfamida
/
Síndrome Nefrótica
Tipo de estudo:
Diagnostic_studies
Limite:
Child, preschool
/
Female
/
Humans
/
Male
Idioma:
En
Revista:
J Pediatr
Ano de publicação:
1975
Tipo de documento:
Article
País de publicação:
Estados Unidos