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An investigation of recurrent pine oil poisoning in an infant by the use of gas chromatographic-mass spectrometric methods.
J Pediatr ; 87(1): 115-8, 1975 Jul.
Article em En | MEDLINE | ID: mdl-1151533
An 18-month-old infant required six hospital admissions in a period of six months for episodes consisting of coughing, respiratory depression, hematemesis, coma, dehydration, and lesions about the mouth. A negative history of ingestion of toxins was repeatedly obtained from the family and two home inspection by the local Health Department failed to identify potential toxins. Metabolic work-up was entirely negative. Utilizing methods of GC-MS, metabolites of a-terpineol were isolated from infant urine on two admissions to the hospital. These metabolites were confirmed by mass spectrometry to be the same metabolites excreted by Sprague-Dawley rats injected with a-terpineol or pine oil. The child had no additional episodes after physical separation from the home environment.
Assuntos
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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Silício / Terpenos / Compostos de Trimetilsilil Tipo de estudo: Prognostic_studies Limite: Animals / Humans / Infant / Male Idioma: En Revista: J Pediatr Ano de publicação: 1975 Tipo de documento: Article País de publicação: Estados Unidos
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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Silício / Terpenos / Compostos de Trimetilsilil Tipo de estudo: Prognostic_studies Limite: Animals / Humans / Infant / Male Idioma: En Revista: J Pediatr Ano de publicação: 1975 Tipo de documento: Article País de publicação: Estados Unidos