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Hormone replacement therapy increases ACTH/dehydroepiandrosterone sulfate in menopause.
Fonseca, E; Basurto, L; Velázquez, S; Zárate, A.
Afiliação
  • Fonseca E; Endocrine Research Unit, Hospital de Especialidades, Centro Médico Nacional, Instituto Mexicano del Seguro Social, Mexico City, Mexico.
Maturitas ; 39(1): 57-62, 2001 Jul 25.
Article em En | MEDLINE | ID: mdl-11451621
OBJECTIVE: To demonstrate that hypoestrogenism in menopause is in part responsible for the decrease in circulating dehydroepiandrosterone sulfate (DHEA-S) and ACTH levels. To test this hypothesis, 25 postmenopausal women aged 47-60 years, were given orally conjugated equine estrogen (CEE) to study the effect on circulating DHEA-S, cortisol and ACTH. DESIGN: A prospective, non-blinded study was performed. Hormonal levels were analyzed before and after three cycles of CEE 0.625 mg/day for 21 days followed each by chlormadinone acetate for 5 days. RESULTS: Low baseline levels of DHEA-S increased significantly after HRT (1.71+/-0.75 to 3.3+/-1.5 micromol/l, (P<0.001). ACTH levels augmented moderately from 3.26+/-1.4 to 4.7+/-1.8 pmol/l (P<0.05) and cortisol from 350.4+/-118 to 450.8+/-144 nmol/l (P<0.01). A positive correlation was obtained between 17 beta-estradiol and ACTH (r=0.48), estradiol and cortisol (r=0.52) as well as estradiol and DHEA-S (r=0.60). In addition, the correlation was highly significant (P<0.001) between ACTH and DHEA-S at the term of HRT. CONCLUSION: HRT increased DHEA-S, ACTH and cortisol concentrations, which may suggest that this therapy may exert a stimulatory effect on the pituitary gland when baseline hypoestrogenism is present, but further studies are required to clarify the mechanism underlying this process.
Assuntos
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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Acetato de Clormadinona / Hormônio Adrenocorticotrópico / Estrogênios Conjugados (USP) / Sulfato de Desidroepiandrosterona / Terapia de Reposição Hormonal / Congêneres da Progesterona Tipo de estudo: Clinical_trials / Observational_studies Limite: Female / Humans / Middle aged Idioma: En Revista: Maturitas Ano de publicação: 2001 Tipo de documento: Article País de afiliação: México País de publicação: Irlanda
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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Acetato de Clormadinona / Hormônio Adrenocorticotrópico / Estrogênios Conjugados (USP) / Sulfato de Desidroepiandrosterona / Terapia de Reposição Hormonal / Congêneres da Progesterona Tipo de estudo: Clinical_trials / Observational_studies Limite: Female / Humans / Middle aged Idioma: En Revista: Maturitas Ano de publicação: 2001 Tipo de documento: Article País de afiliação: México País de publicação: Irlanda