Sleep and memory deficits in the rat produced by experimental infection with Trypanosoma cruzi.
Neurosci Lett
; 306(1-2): 65-8, 2001 Jun 22.
Article
em En
| MEDLINE
| ID: mdl-11403959
We investigated whether the infection with Trypanosoma cruzi in rats could produce functional alterations of the central nervous system. The experimental group received an injection of 150,000 trypomastigotes / rat, whereas the control group received a saline injection. Spontaneous alternation behavior (SAB) tests and sleep-wake cycle recordings were obtained at the end of the parasitaemia. Results showed that the infected animals had significant sleep impairments, as denoted by an increase in the number of wake periods and a reduction of rapid eye movement sleep amount. SAB performance was also found to be impaired in these animals, as compared to the control group. Our results suggest that the rat is a suitable model for brain dysfunction studies in Chagas' disease.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Transtornos do Sono-Vigília
/
Trypanosoma cruzi
/
Encéfalo
/
Doença de Chagas
/
Transtornos da Memória
/
Neurônios
Limite:
Animals
Idioma:
En
Revista:
Neurosci Lett
Ano de publicação:
2001
Tipo de documento:
Article
País de afiliação:
México
País de publicação:
Irlanda