[Secondary serologic responses to dengue epidemic in 1998 in Salta, Argentina, where other flavivirus co-circulate]. / Respuestas serológicas secundarias en la epidemia de dengue de 1998 en Salta, Argentina, donde co-circulan otros flavivirus.
Medicina (B Aires)
; 61(2): 129-36, 2001.
Article
em Es
| MEDLINE
| ID: mdl-11374133
In 1998, a dengue outbreak (serotype 2) occurred in Salta province in Northern Argentina, following the first detection of dengue in the same area in 1997. We classified the serologic response of cases from 1998 as primary or secondary, since the risk of severe disease is greater for secondary cases. We studied 154 cases by plaque reduction neutralization and hemagglutination inhibition tests. Thirty-eight cases (25%) were classified as primary serologic responses and 84 cases (54%) as secondary responses. Thirty-two cases (21%) with borderline IgG titers could not be classified. Previous exposure to potentially cross-reacting flaviviruses (Saint Louis Encephalitis [SLE] and Yellow Fever [YF] viruses) was analyzed, as a possible cause of the secondary response pattern. Our results indicated that among cases classified as dengue secondary response, 83% could be attributed to previous SLE or YF exposure or serologic cross-reactivity. Vaccination against YF virus was at most a minor contributor to the secondary response pattern. The finding of a positive YF serologic result among persons not vaccinated may indicate silent circulation of YF in a region that can support both urban and jungle cycles. Other cases showing dengue secondary responses remained unexplained, suggesting the unrecognized occurrence of a previous infection with other dengue serotypes or of flaviviruses other than SLE or YF.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Febre Amarela
/
Dengue
/
Vírus da Dengue
/
Encefalite de St. Louis
/
Anticorpos Antivirais
Tipo de estudo:
Screening_studies
Limite:
Humans
País/Região como assunto:
America do sul
/
Argentina
Idioma:
Es
Revista:
Medicina (B Aires)
Ano de publicação:
2001
Tipo de documento:
Article
País de afiliação:
Argentina
País de publicação:
Argentina