Photochemistry and phototoxicity studies of flutamide, a phototoxic anti-cancer drug.
J Photochem Photobiol B
; 58(2-3): 108-14, 2000 Nov.
Article
em En
| MEDLINE
| ID: mdl-11233637
The phototoxic anti-cancer drug flutamide is photolabile under UV-B light in either aerobic or anaerobic conditions. Irradiation of a methanol solution of this drug produces several photoproducts, one by photoreduction of the nitro group, one by rupture of the aromatic-NO2 bond of the parent compound, two as a result of the rupture of the CO-NH bond and one derived from the photoreduction product by scission of the aromatic-NH2 bond. Flutamide shows a photohemolytic effect on human erythrocytes and photoinduces lipid peroxidation. Studies on peripheral blood polymorphonuclear cells (neutrophils) demonstrated the phototoxicity of flutamide as well as inhibition of the cytotoxicity respiratory burst by the photoproduct derived from its photoreduction. The results suggest that the inhibition of the respiratory burst observed in phorbol myristate acetate (PMA)-activated cells is mediated by photosensitization and concomitant singlet oxygen production and/or formation of toxic photoproducts.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Antineoplásicos Hormonais
/
Flutamida
Limite:
Humans
Idioma:
En
Revista:
J Photochem Photobiol B
Assunto da revista:
BIOLOGIA
Ano de publicação:
2000
Tipo de documento:
Article
País de afiliação:
Venezuela
País de publicação:
Suíça