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Environmental genotoxicity evaluation using cytogenetic end points in wild rodents.
de Souza Bueno, A M; de Bragança Pereira, C A; Rabello-Gay, M N.
Afiliação
  • de Souza Bueno AM; Universidade Federal de Santa Catarina, Departamento de Biologia Celular, Embriologia e Genética, Florianópolis, Brazil. bueno@ccb.ufsc.br
Environ Health Perspect ; 108(12): 1165-9, 2000 Dec.
Article em En | MEDLINE | ID: mdl-11133397
We analyzed cytogenetic end points in three populations of two species of wild rodents--Akodon montensis and Oryzomys nigripes--living in an industrial, an agricultural, and a preservation area at the Itajaí Valley, state of Santa Catarina, Brazil. Our purpose was to evaluate the performance of the following end points in the establishment of a genotoxic profile of each area: the polychromatic/normochromatic cell ratio; the mitotic index; the frequency of micronucleated cells both in the bone marrow and peripheral blood; and the frequency of cells with chromosome aberrations in the bone marrow. Preparations were obtained using conventional cytogenetic techniques. The results showed a) the role of the end points used as biomarkers in the early detection of genotoxic agents and in the identification of species and populations at higher risk; b) the difference in sensitivity of the species selected as bioindicators in relation to the cytogenetic end points analyzed; c) the need to use at least two sympatric species to detect the presence of genotoxins in each locality; and d) the need to use several end points when trying to establish a genotoxic profile of an area.
Assuntos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Dano ao DNA / Sigmodontinae / Exposição Ambiental / Poluentes Ambientais / Mitose Tipo de estudo: Diagnostic_studies / Evaluation_studies / Screening_studies Limite: Animals Idioma: En Revista: Environ Health Perspect Ano de publicação: 2000 Tipo de documento: Article País de afiliação: Brasil País de publicação: Estados Unidos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Dano ao DNA / Sigmodontinae / Exposição Ambiental / Poluentes Ambientais / Mitose Tipo de estudo: Diagnostic_studies / Evaluation_studies / Screening_studies Limite: Animals Idioma: En Revista: Environ Health Perspect Ano de publicação: 2000 Tipo de documento: Article País de afiliação: Brasil País de publicação: Estados Unidos