[Cisapride does not modify prolonged Q-T interval in patients with liver cirrhosis]. / La cisaprida no altera el intervalo Q-T prolongado en pacientes con cirrosis hepática.
Rev Med Chil
; 128(8): 847-52, 2000 Aug.
Article
em Es
| MEDLINE
| ID: mdl-11129545
BACKGROUND: Abnormal small bowel motility, observed in liver cirrhosis, can be reversed with cisapride. Since both cisapride and liver disease are associated with prolonged QT interval, the possibility of adverse cardiovascular effects might be expected with cisapride treatment in these patients. AIM: To evaluate QT interval and other electrocardiographic changes during long term treatment with cisapride in cirrhotic patients. PATIENTS AND METHODS: Forty seven cirrhotic patients were studied. Electrocardiogram was recorded and the QT interval corrected according to Bazzett's formula was determined (normal value < 0.44 s). Seventeen patients were treated with cisapride, 10 mg tid for seven months and electrocardiographic controls were performed at the end of the treatment. RESULTS: The mean corrected QT interval was 0.46 +/- 0.03 s (range 0.4-0.53). 34 patients (64%) had QTc prolongation (0.47 +/- 0.02 s). Statistically significant higher values of QTc were observed in patients at Child Pugh stage B and C compared to stage A. No statistically significant difference according to the etiology of liver disease, were observed. No changes in mean QTc duration were observed during cisapride treatment. CONCLUSIONS: In spite that a prolonged QTc was a frequent finding in our series of selected patients, no cardiovascular adverse effects were observed with long term cisapride treatment.
Buscar no Google
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Fármacos Gastrointestinais
/
Cisaprida
/
Frequência Cardíaca
/
Cirrose Hepática
Limite:
Adult
/
Aged
/
Female
/
Humans
/
Male
/
Middle aged
Idioma:
Es
Revista:
Rev Med Chil
Ano de publicação:
2000
Tipo de documento:
Article
País de publicação:
Chile