Evidence that chlorophyllin (CHLN) may behave as an inhibitor or a promoter of radiation-induced genetic damage in somatic cells of drosophila.
Mutat Res
; 472(1-2): 71-4, 2000 Dec 20.
Article
em En
| MEDLINE
| ID: mdl-11113699
Irradiation of 96h old Drosophila following a 24h pretreatment with 5% chlorophyllin (CHLN) was delayed 0-4 days. The antimutagenic effect of CHLN in somatic cells monitored by the wing spot test persisted for 3 days after completion of the pretreatment and appeared to terminate at a time corresponding to the cessation of mitotic divisions of wing anlagen cells. Within the same population of cells, CHLN demonstrated both an inhibitory effect as measured in mwh single spot classes, and contrarily, a promoting effect in the class of mwh/flr twin spots and to an extent in the class of large flr spots. The reason for the contrasting effects of CHLN remains to be determined.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Asas de Animais
/
Clorofilídeos
/
Antimutagênicos
/
Drosophila
/
Mutagênicos
Limite:
Animals
Idioma:
En
Revista:
Mutat Res
Ano de publicação:
2000
Tipo de documento:
Article
País de afiliação:
México
País de publicação:
Holanda