Stage specific kinetoplast DNA-binding proteins in Trypanosoma cruzi.
Acta Trop
; 76(2): 139-46, 2000 Sep 18.
Article
em En
| MEDLINE
| ID: mdl-10936573
Knowledge regarding kinetoplast DNA organization in all members of the Trypanosomatid family is incomplete. Recently, the presence of kinetoplast-associated proteins in condensing kDNA networks in Crithidia fasciculata has been described and a role for these proteins in the maintenance of these complex structures was suggested. To investigate the presence of protein components in Trypanosoma cruzi kinetoplast, we previously described seven epimastigote kinetoplast-associated proteins. We report here the existence of kinetoplast binding proteins in amastigote and trypomastigote stages of T. cruzi, which could bind both mini and maxicircles components with a stage specific elements for every infective form of the parasite. We propose three major classes of kinetoplast-associated proteins related to the basic processes of this intricate disc structure and suggest a possible function of these binding proteins in the T. cruzi mitochondrial DNA organization.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Proteínas de Bactérias
/
Trypanosoma cruzi
/
Proteínas de Protozoários
/
DNA de Cinetoplasto
/
Proteínas de Ligação a DNA
Limite:
Animals
/
Humans
Idioma:
En
Revista:
Acta Trop
Ano de publicação:
2000
Tipo de documento:
Article
País de afiliação:
México
País de publicação:
Holanda