Inhibition of the central heme oxygenase-carbon monoxide pathway increases 2-deoxy-D-glucose-induced hypothermia in rats.
Neurosci Lett
; 290(1): 45-8, 2000 Aug 18.
Article
em En
| MEDLINE
| ID: mdl-10925171
The present study was designed to test the hypothesis that carbon monoxide (CO) plays a role in 2-deoxy-D-glucose (2-DG)-induced hypothermia. The body temperature (T(b)) of awake, unrestrained rats was measured before and after systemic administration of 2-DG (50 mg/kg) and intracerebroventricular administration of zinc deuteroporphyrin 2,4-bis glycol (ZnDPBG, a heme-oxygenase inhibitor, 200 nmol/4 microl). We observed a significant reduction in body temperature after 2-DG injection. ZnDPBG alone caused no significant change in body temperature. When the two treatments were combined, 2-DG-induced hypothermia was significantly increased. The data indicate that heme oxygenase-carbon monoxide pathway plays a key role in 2-DG-induced hypothermia, inhibiting 2-DG-induced hypothermia.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Monóxido de Carbono
/
Desoxiglucose
/
Heme Oxigenase (Desciclizante)
/
Hipotermia Induzida
Limite:
Animals
Idioma:
En
Revista:
Neurosci Lett
Ano de publicação:
2000
Tipo de documento:
Article
País de afiliação:
Brasil
País de publicação:
Irlanda