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Immunological and clinical evaluation of chagasic patients subjected to chemotherapy during the acute phase of Trypanosoma cruzi infection 14-30 years ago.
Bahia-Oliveira, L M; Gomes, J A; Cançado, J R; Ferrari, T C; Lemos, E M; Luz, Z M; Moreira, M C; Gazzinelli, G; Correa-Oliveira, R.
Afiliação
  • Bahia-Oliveira LM; Centro de Pesquisas René Rachou-Fundação Oswaldo Cruz, Belo Horizonte, Minas Gerais, Brazil.
J Infect Dis ; 182(2): 634-8, 2000 Aug.
Article em En | MEDLINE | ID: mdl-10915103
We recently evaluated the in vitro proliferative response and interferon (IFN)-gamma production of peripheral blood mononuclear cells from a group of 25 people who were treated for Chagas' disease during the acute phase of Trypanosoma cruzi infection and followed up for a period of 14-30 years. On the basis of the parasitological and serological tests, the individuals were classified as cured (C), dissociated, or not cured (NC). Members of group C (the group without cardiac alterations) presented significantly stronger proliferative response against the parasite antigens, with secretion of high levels of IFN-gamma in comparison with the NC group, raising a question about the role of this cytokine in the curing of human T. cruzi infection. Severe cardiac alterations were observed only in 1 of 25 patients, which suggests that treatment benefited the patients.
Assuntos
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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Doença de Chagas Tipo de estudo: Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Adolescent / Adult / Aged / Humans / Middle aged Idioma: En Revista: J Infect Dis Ano de publicação: 2000 Tipo de documento: Article País de afiliação: Brasil País de publicação: Estados Unidos
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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Doença de Chagas Tipo de estudo: Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Adolescent / Adult / Aged / Humans / Middle aged Idioma: En Revista: J Infect Dis Ano de publicação: 2000 Tipo de documento: Article País de afiliação: Brasil País de publicação: Estados Unidos