A stability-indicating HPLC method to determine cyproterone acetate in tablet formulations.

Segall, A; Vitale, M; Perez, V; Hormaechea, F; Palacios, M; Pizzorno, M T

Segall, A; Vitale, M; Perez, V; Hormaechea, F; Palacios, M; Pizzorno, M T.

Afiliação

Segall A; Cátedra de Control de Calidad de Medicamentos, Facultad de Farmacia y Bioquímica, Universidad de Buenos Aires, Argentina.

Drug Dev Ind Pharm ; 26(8): 867-72, 2000 Aug.

Article em En | MEDLINE | ID: mdl-10900543

RESUMO

A simple and accurate liquid chromatographic method was developed to estimate cyproterone acetate (CA) in pharmaceuticals. The drug was chromatographed on a reversed-phase C18 column. Eluents were monitored at a wavelength of 254 nm utilizing a mixture (60:40) of acetonitrile and water. Solution concentrations were measured on a weight basis to avoid the use of an internal standard. The method was statistically validated for linearity, accuracy, precision, and selectivity. Due to its simplicity and accuracy, we believe that the method can be used for routine quality control analysis. No specific sample preparation is required except for the use of a column guard and a suitable prefilter attached to the syringe.

Assuntos

Antagonistas de Androgênios/química; Acetato de Ciproterona/química; Cromatografia Líquida de Alta Pressão/métodos; Comprimidos

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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Acetato de Ciproterona / Antagonistas de Androgênios Idioma: En Revista: Drug Dev Ind Pharm Ano de publicação: 2000 Tipo de documento: Article País de afiliação: Argentina País de publicação: Reino Unido

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