A stability-indicating HPLC method to determine cyproterone acetate in tablet formulations.
Drug Dev Ind Pharm
; 26(8): 867-72, 2000 Aug.
Article
em En
| MEDLINE
| ID: mdl-10900543
A simple and accurate liquid chromatographic method was developed to estimate cyproterone acetate (CA) in pharmaceuticals. The drug was chromatographed on a reversed-phase C18 column. Eluents were monitored at a wavelength of 254 nm utilizing a mixture (60:40) of acetonitrile and water. Solution concentrations were measured on a weight basis to avoid the use of an internal standard. The method was statistically validated for linearity, accuracy, precision, and selectivity. Due to its simplicity and accuracy, we believe that the method can be used for routine quality control analysis. No specific sample preparation is required except for the use of a column guard and a suitable prefilter attached to the syringe.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Acetato de Ciproterona
/
Antagonistas de Androgênios
Idioma:
En
Revista:
Drug Dev Ind Pharm
Ano de publicação:
2000
Tipo de documento:
Article
País de afiliação:
Argentina
País de publicação:
Reino Unido