Chloramphenicol induces apoptosis in the developing brain.
Neuropharmacology
; 39(9): 1673-9, 2000 Jul 10.
Article
em En
| MEDLINE
| ID: mdl-10854912
Programmed cell death was studied in the superior colliculus of the developing rat brain following injections of chloramphenicol. Neonatal rats were either subject to unilateral eye removal or left untouched. Following a 3-h post-operative survival, the animals were perfused with fixatives and frozen sections of their brains were examined for apoptosis after either neutral-red staining, in situ nick-end labeling of fragmented DNA, or immunocytochemistry to activated caspase-3. Chloramphenicol induced apoptosis in control brains and potentiated cell death in deafferented superior colliculi. The results show that CMP has a general pro-apoptotic effect in the developing brain.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Encéfalo
/
Inibidores da Síntese de Proteínas
/
Cloranfenicol
/
Apoptose
Limite:
Animals
Idioma:
En
Revista:
Neuropharmacology
Ano de publicação:
2000
Tipo de documento:
Article
País de afiliação:
Brasil
País de publicação:
Reino Unido