Neonatal hypoxia and pulmonary vasospasm: response to tolazoline.
J Pediatr
; 89(4): 617-21, 1976 Oct.
Article
em En
| MEDLINE
| ID: mdl-1085352
Forty-six neonates with hypoxemia were treated with tolazoline, a pulmonary vasodilator, within the first two days of life. Eight of ten (80%) infants without apparent lung disease responded with a mean increase in PaO2 of 116 torr within one hour of beginning tolazoline infusions. One of the responding infants and two nonresponders died. Thirty-six additional infants with a variety of pulmonary disorders had severe hypoxemia which was refractory to mechanical ventilation. Twenty-one (58%) responded with a mean increase in PaO2 of 130 torr within one hour after beginning tolazoline and 13 (62%) of these survived. Fifteen patients had little or no improvement in PaO2 following tolazoline and only three (20%) of these infants survived. Responders could not be distinguished from nonresponders by clinical or laboratory features prior to therapy with tolazoline. Fourteen infants experienced complications possibly related to tolazoline.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Tolazolina
/
Circulação Pulmonar
/
Doenças do Recém-Nascido
/
Pneumopatias
/
Hipóxia
Limite:
Female
/
Humans
/
Male
/
Newborn
Idioma:
En
Revista:
J Pediatr
Ano de publicação:
1976
Tipo de documento:
Article
País de publicação:
Estados Unidos