Gender differences in the cardiovascular responses to morphine and naloxone in spinal rats.
Eur J Pharmacol
; 397(1): 121-8, 2000 May 26.
Article
em En
| MEDLINE
| ID: mdl-10844106
Putative gender differences in opiate cardiovascular effects were evaluated in spinal rats. After a 4-h exposure to a single dose of morphine (30 mg/kg, i.v.), abstinence was precipitated by naloxone (0.03-3 mg/kg, i.v.). Morphine produced a long-lasting bradycardia and a transient increase in arterial pressure that was similar in both genders. Thereafter, blood pressure decreased both in males and females. Naloxone precipitated a similar dose-dependent heart rate increase in both sexes and a gender-dependent increase in blood pressure. This sex difference appeared in the shape of the response. Prazosin (0.2 mg/kg), prior to naloxone, reduced the pressor response in all animals, suggesting a similar participation of the noradrenergic system in both genders. The present results extend to acute dependence the notion of a sex-dependent differential effect of morphine. The need to consider gender as a factor when studying the effects of opioids is highlighted.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Medula Espinal
/
Sistema Cardiovascular
/
Analgésicos Opioides
/
Morfina
/
Naloxona
/
Antagonistas de Entorpecentes
Aspecto:
Determinantes_sociais_saude
Limite:
Animals
Idioma:
En
Revista:
Eur J Pharmacol
Ano de publicação:
2000
Tipo de documento:
Article
País de afiliação:
México
País de publicação:
Holanda