IgG2 immunodeficiency: association to pediatric patients with bacterial meningoencephalitis.
Arq Neuropsiquiatr
; 58(1): 141-5, 2000 Mar.
Article
em En
| MEDLINE
| ID: mdl-10770879
An IgG subclass deficiency is often associated with bacterial infections. We studied four pediatric patients suffering from meningoencephalitis, two of them due to Streptococcus pneumoniae and two due to Haemophilus influenzae type b. Simultaneous diagnostic serum and cerebrospinal fluid samples were taken during income. The four subclasses of IgG and albumin were quantified in both biologic fluids by radial immunodiffusion. Very low levels of seric IgG2 with non detectable cerebrospinal fluid IgG2 were found in the patients. No intrathecal IgG subclass synthesis was found in two patients. One patient with S. pneumoniae had IgG3 intrathecal synthesis. Intrathecal IgG1, IgG3 and IgG4 synthesis was found in one patient suffering from H. influenzae according with reibergrams. Substitutive therapy with intravenous gammaglobulin was given to the patients as part of the treatment.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Infecções Bacterianas
/
Deficiência de IgG
/
Meningoencefalite
Tipo de estudo:
Risk_factors_studies
Limite:
Child, preschool
/
Humans
/
Infant
/
Newborn
Idioma:
En
Revista:
Arq Neuropsiquiatr
Ano de publicação:
2000
Tipo de documento:
Article
País de afiliação:
Cuba
País de publicação:
Alemanha