Interaction of alpha-melanotropin (alpha-MSH) and noradrenaline in the median eminence in the control of female sexual behavior.
Peptides
; 21(2): 219-23, 2000 Feb.
Article
em En
| MEDLINE
| ID: mdl-10764948
In the present study, we examined the effects of the injection of alpha-melanotropin (alpha-MSH), noradrenaline (NA), and dopamine in the median eminence of ovariectomized-adrenalectomized rats on female sexual behavior. The animals were primed with l0 microg of estradiol benzoate, and 52-54 h later they were injected into the median eminence with either 1 microl of artificial cerebrospinal fluid, 1 microg/rat alpha-MSH, 200 ng/rat NA, 200 ng or 2 microg/rat dopamine, in 1 microl of artificial cerebrospinal fluid. Both alpha-MSH and NA significantly stimulated sexual behavior. This effect was antagonized by two beta-adrenergic antagonists: propranolol (500 ng/rat) and metoprolol (400 ng/rat) applied 15 min before the alpha-MSH or NA. The alpha-adrenergic antagonist prazosine (500 ng/rat) was ineffective in reducing the effect of alpha-MSH. The vehicle and dopamine at both doses had no effect on sexual activity. These results indicate that alpha-MSH and NA in the median eminence stimulate female sexual behavior and that NA mediates the action of alpha-MSH via beta-receptors.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Comportamento Sexual Animal
/
Alfa-MSH
/
Norepinefrina
/
Eminência Mediana
Limite:
Animals
Idioma:
En
Revista:
Peptides
Ano de publicação:
2000
Tipo de documento:
Article
País de afiliação:
Argentina
País de publicação:
Estados Unidos