[Morphometric analysis of nuclear variations in normal and neoplastic mammary ductal cells]. / Análisis morfométrico de variables en núcleos de células ductales normales y neoplásicas de la glándula mamaria. Informe preliminar.
Invest Clin
; 40(4): 233-44, 1999 Dec.
Article
em Es
| MEDLINE
| ID: mdl-10666950
Morphometry is a method to detect changes in a variety of tissues through quantitative elements. The purpose of this study was to examine several nuclear morphologic characteristics in normal and neoplastic mammary ductal cells using a multivariable method and expression of estrogen receptors by immunohistochemical techniques. A total of 1879 nuclei were examined by a computerized program, following the detection of estrogen receptors. Nuclear area, perimeter, diameter, maximal and minimal radio were obtained in 439 normal ductal nuclei. The mean nuclear area was 14.45 with a range between 10.88 and 17.90. Variables showed adequate statistical correlation (r > 0.5). A total of 1440 neoplastic nuclei were classified as grades I, II and III, and a statistical significative difference was found between these three groups. We conclude that the nuclear area is a reliable variable for statistical correlation being the ductal nuclei anisotropic objects.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Mama
/
Neoplasias da Mama
/
Núcleo Celular
Limite:
Adult
/
Aged
/
Aged80
/
Female
/
Humans
/
Middle aged
Idioma:
Es
Revista:
Invest Clin
Ano de publicação:
1999
Tipo de documento:
Article
País de publicação:
Venezuela