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In vivo efficacy of mefloquine for the treatment of Falciparum malaria in Brazil.
Cerutti, C; Durlacher, R R; de Alencar, F E; Segurado, A A; Pang, L W.
Afiliação
  • Cerutti C; Infectious and Parasitic Diseases Department, University of São Paulo, São Paulo, Brazil.
J Infect Dis ; 180(6): 2077-80, 1999 Dec.
Article em En | MEDLINE | ID: mdl-10558975
Ninety-four patients with falciparum malaria were treated with mefloquine (1000-mg single dose) and remained hospitalized in a malaria-free area for a minimum of 28 days. There was 1 parasitologic failure (grade I resistance [RI]) for a 99% cure rate (95% confidence interval, 94.2%-99.7%). Mean parasite clearance time by thick smear was 45.7 h (SD, 11.4 h). The subject in whom therapy failed had a parasite clearance time (71 h) >2 SD above the population mean. His plasma mefloquine level 48 h after administration was lower (578 ng/mL) than the range of levels from 8 randomly selected cured subjects (834-2360 ng/mL). The IC50 to mefloquine for the recrudescent strain of the RI failure was in the upper 90th percentile of IC50 values from 30 cured subjects. These results show a high mefloquine cure rate but document the onset and mechanism of the emergence of resistance.
Assuntos
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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Mefloquina / Malária Falciparum / Antimaláricos Limite: Adolescent / Adult / Animals / Humans / Male / Middle aged País/Região como assunto: America do sul / Brasil Idioma: En Revista: J Infect Dis Ano de publicação: 1999 Tipo de documento: Article País de afiliação: Brasil País de publicação: Estados Unidos
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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Mefloquina / Malária Falciparum / Antimaláricos Limite: Adolescent / Adult / Animals / Humans / Male / Middle aged País/Região como assunto: America do sul / Brasil Idioma: En Revista: J Infect Dis Ano de publicação: 1999 Tipo de documento: Article País de afiliação: Brasil País de publicação: Estados Unidos