Preexposure to drug administration context blocks the development of tolerance to sedative effects of diazepam.
Pharmacol Biochem Behav
; 64(3): 473-7, 1999 Nov.
Article
em En
| MEDLINE
| ID: mdl-10548258
The development of tolerance to benzodiazepine (BDZ) and other psychoactive agents such as morphine, alcohol, and barbiturates is thought to be a contingent or learning phenomenon. In a previous report, we demonstrated a positive correlation between the development of tolerance to the sedative effects of diazepam (DZ) and hippocampal synaptic plasticity. The results of the present work show that the development of tolerance to the hypolocomotor action of DZ (5 mg/kg) for 4 days and the associated increase in synaptic plasticity are context specific. Because animal preexposure to the drug administration context blocks both the tolerance sedative effects of DZ and the increased hippocampal synaptic plasticity, observed after 4 days of DZ administration, we propose the increased synaptic plasticity on hippocampal development as one of the biological substrates to the tolerance to DZ. Besides, the continuous administration of DZ did not induce a conditioning opponent response in these animals.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Diazepam
/
Hipnóticos e Sedativos
Limite:
Animals
Idioma:
En
Revista:
Pharmacol Biochem Behav
Ano de publicação:
1999
Tipo de documento:
Article
País de afiliação:
Argentina
País de publicação:
Estados Unidos